RCGD423 a small molecule gp130 modulator prevents articular cartilage degeneration and promotes repair.

Pimonidazole hydrochloride accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group.

3-Methyladipic acid is a metabolite of the catabolism of phytanic acid. Patients with adult Refsums disease (ARD) are unable to detoxify phytanic acid by alpha-oxidation and so the w-oxidation pathway is the only metabolic pathway available for phytanic acid degradation.